Volume 72 (2025) Issue 12
GPR75 signaling is dispensable for reproduction but contributes to feeding and body growth in rats on normal chow and is involved in high-fat diet-induced hyperphagia, obesity, and hyperglycemia development
Yuki Otsuka, Naoko Inoue, Safiullah Hazim, Shunsuke Seki, Hitomi Tsuchida, Mayuko Nagae, Yusuke Sugimoto, Daiki Kasugai, Kyoko Yogo, Marina Nakanishi, Nahoko Ieda, Teppei Goto, Masumi Hirabayashi, Hiroko Tsukamura, Yoshihisa Uenoyama
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Recommendation from the Editor in Chief
Inter-relationship between body weight regulation and fertility has long fascinated researchers and clinicians in the area of endocrinology. However, an avalanche of enigmas still remains around the molecular mechanism. In this issue, Dr. Yuki Otsuka, Dr. Yoshitaka Uenoyama, Professor Hiroko Tsukamura and colleague at Nagoya University unravel a role of “orphan ligand” receptor, GPR75, in the control of appetite and reproduction in knockout rat models. Because loss of function variants of GPR75 gene is implicated in the protection of obesity in humans via the worldwide, large-scale exome sequencing, this excellent article provides all readers with fresh avenue to integrate the latest genome science and such a sophisticated basic research.