Masaya Koshizaka, Hidetaka Yokoh, Ko Ishikawa, Aiko Hayashi, Yukari Maeda, Jin Kumagai, Kenji Takeda, Hiyori Kaneko, Tomohiro Ohno, Hiraku Ono, Yusuke Hirota, Takayoshi Sasako, Takashi Kato, Kengo Miyoshi, Toshimasa Yamauchi, Hirotaka Watanabe, Takaaki Sakaue, Mitsuyoshi Takahara, Iichiro Shimomura, Atsuhito Saiki, Ichiro Tatsuno, Kazuhisa Takahashi, Satoshi Kurose, Yutaka Kimura, Takeshi Onoue, Tomoko Handa, Hiroshi Arima, Jun Eguchi, Jun Wada, Aika Miya, Toru Kusakabe, Noriko Satoh-Asahara, Junichiro Irie, Nobuko Yamada-Goto, Masahiro Kondo, Kengo Nagashima, Yasunori Sato, Shigeru Miyazaki, Hiroko Yamamoto, Yoshie Kondo, Masako Waki, Hiroaki Ueno, Masamitsu Nakazato, Yoshiro Nakayama, Hiroaki Masuzaki, Takayuki Masaki, Masayuki Ohta, Masahiro Nishi, Makito Tanabe, Ryuya Iwamoto, Takafumi Senokuchi, Takuro Horikoshi, Kazuyo Tsushita, Takashi Kadowaki, Koutaro Yokote, SLIM-TARGET study group
Recommendation from the Editor
Our understanding of aldosterone-producing adenomas (APAs) has advanced substantially since the discovery of recurrent somatic mutations, particularly in KCNJ5. Recent single-cell and spatial transcriptomic studies have further revealed cellular and functional heterogeneity within individual APAs. In this issue, Dr. Masanori Murakami at Institute of Science Tokyo reviews recent findings on the inter- and intratumoral heterogeneity of APAs and discusses their clinical implications. This review provides readers with an updated perspective on APA pathophysiology and the evolving understanding of its molecular and cellular heterogeneity.