Yuichiro Iwamoto, Tomohiko Kimura, Masato Kubo, Yui Okamoto, Ryo Inaba, Takashi Itoh, Toshitomo Sugisaki, Kazunori Dan, Hideyuki Iwamoto, Yoshiro Fushimi, Junpei Sanada, Hayato Isobe, Fuminori Tatsumi, Yukiko Kimura, Fumiko Kawasaki, Masashi Shimoda, Shuhei Nakanishi, Kohei Kaku, Hideaki Kaneto
Recommendation from the Editor
The pituitary gland is a master endocrine organ regulating diverse physiological functions via coordinated hormone secretion. Although the molecular mechanisms underlying pituitary development and disorders have been extensively studied in animal models, significant species-specific differences limit the direct translation of these findings to human biology. In this issue, Dr. Ryusaku Matsumoto at Kyoto University and his colleagues contribute an excellent review comprehensively summarizing current human cell-based in vitro models for investigating pituitary development and disorders. They systematically discuss the advantages and limitations of available experimental platforms, ranging from conventional two-dimensional cell lines and primary tumor cultures to cutting-edge three-dimensional organoid systems derived from pituitary tumor tissues and human pluripotent stem cells. Our editorial team is confident that this timely and insightful review will provide readers with up-to-date knowledge of this rapidly evolving field and serve as a valuable resource for researchers and clinicians engaged in pituitary biology and endocrine medicine.