Shoichiro Izawa, Kazuhisa Matsumoto, Kanako Kadowaki, Toshifumi Nakamura, Norio Wada, Takuyuki Katabami, Yoichi Nozato, Ryuji Okamoto, Takamasa Ichijo, Daisuke Taura, Masanori Murakami, Miki Kakutani, Takashi Yoneda, Minemori Watanabe, Yutaka Takahashi, Shintaro Okamura, Katsutoshi Takahashi, Hiroki Kobayashi, Mitsuhide Naruse, Kenichi Yokota, Masakatsu Sone, the JPAS-II Study Group
Recommendation from the Editor
Establishing the cutoff values that indicate the need for adrenal venous sampling (AVS) for accurate diagnosis of unilateral primary aldosteronism (UPA) has been desired. In this issue, Dr Shoichiro Izawa in Tottori University and the JPAS-II Study Group members conducted a retrospective cohort analysis of 443 patients with PA and clearly identified the cutoff values for AVS, based on LC–MS/MS-equivalent CLEIA-measured, as aldosterone-to-renin ratio(ARR)of >153 pg/mL/ng/mL/h after captopril challenge test (CCT) and plasma aldosterone concentration (PAC) of >48 pg/mL after saline infusion test (SIT). Our editorial team is confident that this excellent paper will be helpful for clinicians and endocrinologists in deciding whether or not to perform AVS.