ORIGINAL
Real-world optimization of cutoff values for enzyme immunoassay-based plasma-free fractionated metanephrines for the diagnosis of pheochromocytoma and paraganglioma: a multicenter retrospective study

Masato Yonamine, Ryota Ishii, Katsutoshi Takahashi, Yuichi Aita, Yuki Murayama, Motohiro Sekiya, Koichi Ozaki, Jun Saito, Moe Horinaka, Akiyo Tanabe, Yuka Ohmachi, Masaaki Yamamoto, Hidenori Fukuoka, Rei Hirose, Kazuhiro Takekoshi

https://doi.org/10.1507/endocrj.EJ26-0101
July 8, 2026
CLINICAL PRACTICE GUIDELINE
Diagnostic criteria for adrenal overt Cushing syndrome: prepared jointly by the Japan Endocrine Society and the Health and Labour Sciences Research Grant (Research on Intractable Diseases) Research Group on Disorders of Adrenal Hormones

Takuyuki Katabami, Hirotaka Shibata, Akiyo Tanabe, Masakatsu Sone, Michio Otsuki, Yoshihiro Ogawa, Tomoatsu Mune, Takamasa Ichijo, Yuichi Yoshida, Takashi Yoneda, Kazuhiko Horiguchi, Katsutoshi Takahashi, Mitsuru Nishiyama, Fumitoshi Sato, Isao Kurihara, Makito Tanabe, Toshihiro Tajima, Tomonobu Hasegawa, Tomohiro Ishii

https://doi.org/10.1507/endocrj.EJ26-0077
July 7, 2026
ORIGINAL
Clinical characterization of Japanese children with Cushing’s disease

Mari Yamamoto, Yuri Mukoyama, Kentaro Kishi, Shun Moriguchi, Fumihiko Takizawa, Tetsushi Ogawa, Junko Ito, Susumu Yokoya, Hirokazu Fukuhara, Noriaki Fukuhara, Masahiko Tosaka, Hiroshi Nishioka, Shozo Yamada, Masakazu Mimaki, Tsuyoshi Isojima

https://doi.org/10.1507/endocrj.EJ26-0212
July 2, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Early diagnosis of capivasertib-associated severe hyperglycemia with diabetic ketosis diagnosed in routine clinical practice: a case report with review of literature

Masashi Yoshikawa, Keiichiro Takahashi, Satoshi Yoshino, Yutaka Watanuki, Aya Osaki, Hiroki Ito, Masaya Uehara, Keiko Tanabe, Sasagu Kurozumi, Shunichi Matsumoto, Kazuhiko Horiguchi, Eijiro Yamada

https://doi.org/10.1507/endocrj.EJ26-0035
July 1, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Teprotumumab-associated persistent unilateral hearing loss in dysthyroid optic neuropathy: a case report with review of the literature

Yuji Hiromatsu, Kumiko Suzuki, Shiho Watanabe, Takahiro Fukuyama, Narihito Tatsumoto, Satoe Nakamura, Yoko Sagara, Yuko Akehi, Eiji Kawasaki, Hiroki Kojima, Kimihiko Sakai

https://doi.org/10.1507/endocrj.EJ26-0064
July 1, 2026
ORIGINAL
Associations of stress hormones, autonomic function, and endothelial function in patients with diabetes

Takanobu Saheki, Keisuke Takahashi, Eri Harada, Takafumi Yoshimura, Toshihiro Kobayashi, Kensaku Fukunaga, Hitomi Imachi, Koji Murao

https://doi.org/10.1507/endocrj.EJ26-0067
June 27, 2026
REVIEW
Inter- and intratumoral heterogeneity of aldosterone-producing adenomas: recent advances and clinical implications

Masanori Murakami

https://doi.org/10.1507/endocrj.EJ26-0125
June 24, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Metachronous multiple insulinomas in oculo-facio-cardio-dental syndrome harboring a novel BCOR deletion: a case report with review of literature

Shinsuke Noso, Hiroki Miki, Yoshihisa Hiromine, Naru Babaya, Yasunori Taketomo, Sawa Yoshida, Katsuya Ami, Ippei Matsumoto, Norikazu Maeda

https://doi.org/10.1507/endocrj.EJ26-0090
June 20, 2026
ORIGINAL
Establishment of a prognostic score for distant recurrence in follicular thyroid carcinoma

Yasuhiro Ito, Masashi Yamamoto, Mitsuyoshi Hirokawa, Hiroo Masuoka, Minoru Kihara, Akihiro Miya, Akira Miyauchi, Takashi Akamizu

https://doi.org/10.1507/endocrj.EJ26-0184
June 13, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Recurrent Cushing’s disease due to postoperative seeding of tumor cells in the sphenoid sinus: a case report with review of the literature

Tatsuma Matsuda, Noriaki Fukuhara, Masahiko Tosaka, Kentaro Horiguchi, Yoshinori Higuchi, Hiroshi Nishioka

https://doi.org/10.1507/endocrj.EJ26-0008
June 9, 2026
ORIGINAL
The clinical significance of SIGLEC1 mRNA levels derived from peripheral leukocytes in autoimmune thyroid diseases and type 1 diabetes

Mami Gamo-Kawasaki, Shiori Kawai, Ayano Takei, Kazunori Fukuda, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Koshi Hashimoto

https://doi.org/10.1507/endocrj.EJ25-0639
June 2, 2026
ORIGINAL
Effect of social jetlag on metabolic syndrome varies by body mass index: evidence from Taiwan Biobank

Shih-Kai Kao, Kai-Hsuan Cheng, Jerry Cheng-Yen Lai, Shaw-Ji Chen , Meng-Ying Lu

https://doi.org/10.1507/endocrj.EJ26-0018
May 29, 2026
REVIEW
Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease

Takahito Miyake, Masao Doi

https://doi.org/10.1507/endocrj.EJ26-0148
May 29, 2026
ORIGINAL
Telomere length in patients with non-functional adrenal incidentalomas

Nilufer Ozdemir, Seda Sabah Ozcan, Ayse Ece Turkmen, Sedat Can Guney, Zeliha Hekimsoy, Mehmet Korkmaz

https://doi.org/10.1507/endocrj.EJ26-0033
May 27, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Multimodal management of giant prolactinoma with extensive amyloid spherule deposition: a case report with review of the literature

Aysel Unver Ozkahraman, Merve Korkmaz Yilmaz, Huseyin Karatay, Sidar Bagbudar, Ebubekir Akpinar, Buruc Erkan, Mehmet Karagulle, Mesut Yilmaz, Mutlu Niyazoglu, Esra Hatipoglu

https://doi.org/10.1507/endocrj.EJ26-0079
May 27, 2026
ORIGINAL
Differentiating TRAb-positive painless thyroiditis from Graves’ disease using biochemical and ultrasound findings

Yoshiki Furumura, Mitsuru Ito, Itaru Monno, Keitaro Miyamura, Shuji Fukata, Eijun Nishihara, Mitsushige Nishikawa, Akira Miyauchi, Takashi Akamizu

https://doi.org/10.1507/endocrj.EJ26-0047
May 20, 2026
ORIGINAL
Indicators for predicting continuous insulin infusion therapy-related hypokalemia: multicenter retrospective cohort study

Yuichiro Iwamoto, Tomohiko Kimura, Masato Kubo, Yui Okamoto, Ryo Inaba, Takashi Itoh, Toshitomo Sugisaki, Kazunori Dan, Hideyuki Iwamoto, Yoshiro Fushimi, Junpei Sanada, Hayato Isobe, Fuminori Tatsumi, Yukiko Kimura, Fumiko Kawasaki, Masashi Shimoda, Shuhei Nakanishi, Kohei Kaku, Hideaki Kaneto

https://doi.org/10.1507/endocrj.EJ26-0061
May 16, 2026
ORIGINAL
From cross-section to prognosis: risk factors for renal function deterioration in primary hyperparathyroidism

Takuma Yamoto, Masakazu Notsu, Keizo Kanasaki

https://doi.org/10.1507/endocrj.EJ25-0616
May 15, 2026
ORIGINAL
Efficacy and safety of dabrafenib plus trametinib in BRAFV600E-mutated advanced thyroid carcinoma: Real world experience in 37 patients

Haruhiko Yamazaki, Nobuyasu Suganuma, Mei Kadoya, Katsuhiko Masudo, Ai Matsui, Aya Saito

https://doi.org/10.1507/endocrj.EJ25-0629
May 14, 2026
ORIGINAL
γ-Secretase inhibitor ameliorates thyroid autoimmune damage via blocking Notch1 signaling and reducing γδT17 cells in EAT mice

Jue Wang, Longfei Ding, Chengyan He, Hao Liu, Yiwen Li, Yujiao Zhu, Yue Li, Haibo Xue

https://doi.org/10.1507/endocrj.EJ25-0663
May 13, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Acanthosis nigricans as a diagnostic clue for familial partial lipodystrophy type 2: a case report with review of literature on Japanese cases

Takuya Kitamura, Toru Kusakabe, Yuki Ishihara, Tetsuya Tagami, Kazuwa Nakao

https://doi.org/10.1507/endocrj.EJ25-0487
May 12, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Anti–pituitary-specific transcription factor-1 hypophysitis developing after thymoma resection: a case report with review of literature

Hitomi Konishi, Yui Yamashita, Yuma Motomura, Shin Urai, Yumiko Sasai, Keiko Yamagami, Hironori Bando, Naotetsu Kanamoto

https://doi.org/10.1507/endocrj.EJ26-0108
May 12, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Overlap syndrome between sarcoidosis and Sjögren’s disease presenting as hypopituitarism: case report and review of literature

Yuichiro Iwamoto, Noriko Yoshimura, Ayaka Harada, Yoshiro Fushimi, Yui Okamoto, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Yo Mizuta, Saeko Tsurui, Seiji Matsumoto, Yoshikazu Koike, Takehiro Nishimura, Hideaki Kaneto

https://doi.org/10.1507/endocrj.EJ26-0063
May 8, 2026
REVIEW
Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting

Qi Zhu, Yu Liu, Chen Yang, Tie Li

https://doi.org/10.1507/endocrj.EJ26-0050
April 29, 2026
ORIGINAL
Machine learning-based prediction of impaired arginine vasopressin secretion during hypertonic saline test

Satoshi Naito, Daisuke Hagiwara, Masaki Kitamura, Ryosei Ashida, Yohei Kawaguchi, Takashi Miyata, Tomoko Handa, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima

https://doi.org/10.1507/endocrj.EJ26-0094
April 25, 2026
CASE REPORT WITH REVIEW OF LITERATURE
Long-term survival in MIRAGE syndrome: Insights into systemic manifestations and management with review of literature

Yuki Yamada, Hidehito Kondo, Masashi Nishida, Zenro Kizaki, Kanako Tanase-Nakao, Satoshi Narumi, Jun Mori

https://doi.org/10.1507/endocrj.EJ25-0656
April 23, 2026
ORIGINAL
ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease

Anni Li, Yuxuan Ye, Huimin Cao, Jiawei Hu, Min Shi, Juan Zhang, Yiyuan Zhang, Yuting Liu, Bixia Gu, Hong Zhang

https://doi.org/10.1507/endocrj.EJ25-0648
April 18, 2026
REVIEW
Emerging human cell-based in vitro models for studying pituitary development and disorders

Ryusaku Matsumoto, Ayaka Nishio, Yutaka Takahashi, Takuya Yamamoto

https://doi.org/10.1507/endocrj.EJ25-0601
Featured Article Vol 73 Issue 7 (July, 2026)
ESSAY | TOWARD JES 100TH ANNIVERSARY
Corticotropin-releasing factor as a regulator of adrenal glucocorticoid synthesis and brain function: a scientific journey of a neuroendocrine physician

Keiichi Itoi

https://doi.org/10.1507/endocrj.EJ20260203
Vol 73 Issue 7 (July, 2026)
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Double faces of pheochromocytoma and paraganglioma—a review of integrated pathologic diagnosis

Noriko Kimura

https://doi.org/10.1507/endocrj.EJ25-0559
Vol 73 Issue 7 (July, 2026)
ORIGINAL
Association of hypothyroidism with adverse pregnancy outcomes: a single-center cohort study in an iodine-sufficient country

Akiko Sankoda, Nagayoshi Umehara, Yusuke Okubo, Shiori Sato, Seiji Wada, Naoko Arata

https://doi.org/10.1507/endocrj.EJ25-0423
Vol 73 Issue 7 (July, 2026)
ORIGINAL
Early predictors of 6-month thyroid-stimulating antibody levels after radioactive iodine therapy for Graves’ disease: implications for pregnancy planning

Seigo Tachibana, Yuji Nagayama, Takashi Fukuda, Yusuke Taguchi, Daisuke Tatsushima, Yusuke Mori, Hisakazu Shindo, Hiroshi Takahashi, Shinya Sato, Hiroyuki Yamashita

https://doi.org/10.1507/endocrj.EJ25-0651
Vol 73 Issue 7 (July, 2026)
ORIGINAL
Nationwide survey on iodine nutritional status and thyroid function in Japanese adults

Yozen Fuse, Yo Kunii, Nobu Tsukada, Yoshiya Ito, Yoshimasa Shishiba

https://doi.org/10.1507/endocrj.EJ25-0603
Vol 73 Issue 7 (July, 2026)
ORIGINAL
A predictive nomogram for progression-free survival in radioiodine-refractory papillary thyroid carcinoma after reoperation: a longitudinal study in Vietnam

Nguyen Thi Nhung, Le Ngoc Ha, Van Dong Hoang, Zhanna Mussazhanova, Hirokazu Kurohama, Katsuya Matsuda, Yuki Matsuoka, Le Thi Khanh Tam, Ngo Thi Minh Hanh, Van Phu Thang Nguyen, Thi Ngoc Anh Nguyen, Tratsiakova Katsiaryna, Michiko Matsuse, Norisato Mitsutake, Masahiro Nakashima

https://doi.org/10.1507/endocrj.EJ25-0565
Vol 73 Issue 7 (July, 2026)
ORIGINAL
Multiple thyroid cysts: a benign and stable clinical entity based on longitudinal data

Yuji Nagayama, Seigo Tachibana, Takashi Fukuda, Daisuke Tatsushima, Yusuke Mori, Hisakazu Shindo, Hiroshi Takahashi, Shinya Sato, Hiroyuki Yamashita

https://doi.org/10.1507/endocrj.EJ25-0573
Vol 73 Issue 7 (July, 2026)
CASE REPORT WITH REVIEW OF LITERATURE
Efficacy of iodine-131-metaiodobenzylguanidine therapy for multiple endocrine neoplasia type 2A-associated metastatic pheochromocytoma: case report and literature review

Kentaro Suda, Noriko Kimura, Toshihiro Maeda, Shiro Watanabe, Sachiyo Nishida, Hiroaki Shima, Taro Sugawara, Shinya Uchino, Aki Ishikawa, Toshiaki Tanaka, Masato Furuhashi, Naoya Masumori, Akihiro Sakurai

https://doi.org/10.1507/endocrj.EJ25-0486
Vol 73 Issue 7 (July, 2026)
CASE REPORT WITH REVIEW OF LITERATURE
Low-affinity IgG-mediated macro-TSH: diagnostic limitations of peak-based gel filtration chromatography—a case report with review of literature

Toshihiko Kasahara

https://doi.org/10.1507/endocrj.EJ26-0019
Vol 73 Issue 7 (July, 2026)

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Volume 73 (2026) Issue 7

EJ25-0601

Recommendation from the Editor

The pituitary gland is a master endocrine organ regulating diverse physiological functions via coordinated hormone secretion. Although the molecular mechanisms underlying pituitary development and disorders have been extensively studied in animal models, significant species-specific differences limit the direct translation of these findings to human biology. In this issue, Dr. Ryusaku Matsumoto at Kyoto University and his colleagues contribute an excellent review comprehensively summarizing current human cell-based in vitro models for investigating pituitary development and disorders. They systematically discuss the advantages and limitations of available experimental platforms, ranging from conventional two-dimensional cell lines and primary tumor cultures to cutting-edge three-dimensional organoid systems derived from pituitary tumor tissues and human pluripotent stem cells. Our editorial team is confident that this timely and insightful review will provide readers with up-to-date knowledge of this rapidly evolving field and serve as a valuable resource for researchers and clinicians engaged in pituitary biology and endocrine medicine.

Emerging human cell-based in vitro models for studying pituitary development and disorders

Ryusaku Matsumoto, Ayaka Nishio, Yutaka Takahashi, Takuya Yamamoto

https://doi.org/10.1507/endocrj.EJ25-0601

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