Metabolic zonation in liver has been highlighted in terms of hepatic carbohydrate and lipid metabolism in both physiology and pathophysiology as well as in molecular bases for a line of intractable liver diseases. In this issue, Dr. Masanori Fujimoto and Professor Tomoaki Tanaka at Chiba University contribute a well-organized, comprehensive review article particularly focusing on recent research progress of metabolic zonation in liver enabled by single-cell and spatial omics technologies. We have a firm belief that this article gives all readers in a variety of clinical and research fields a valuable hint to expand and extend individual expertise.
![EJ25-0140](https://endocrine-j.jp/wp-content/uploads/EJ25-0140FA.jpg")
Recommendation from the Editor in Chief
Metabolic zonation in liver has been highlighted in terms of hepatic carbohydrate and lipid metabolism in both physiology and pathophysiology as well as in molecular bases for a line of intractable liver diseases. In this issue, Dr. Masanori Fujimoto and Professor Tomoaki Tanaka at Chiba University contribute a well-organized, comprehensive review article particularly focusing on recent research progress of metabolic zonation in liver enabled by single-cell and spatial omics technologies. We have a firm belief that this article gives all readers in a variety of clinical and research fields a valuable hint to expand and extend individual expertise.