Our understanding of aldosterone-producing adenomas (APAs) has advanced substantially since the discovery of recurrent somatic mutations, particularly in KCNJ5. Recent single-cell and spatial transcriptomic studies have further revealed cellular and functional heterogeneity within individual APAs. In this issue, Dr. Masanori Murakami at Institute of Science Tokyo reviews recent findings on the inter- and intratumoral heterogeneity of APAs and discusses their clinical implications. This review provides readers with an updated perspective on APA pathophysiology and the evolving understanding of its molecular and cellular heterogeneity.
![EJ26-0125](https://endocrine-j.jp/wp-content/uploads/EJ26-0125FA.jpg")
Recommendation from the Editor
Our understanding of aldosterone-producing adenomas (APAs) has advanced substantially since the discovery of recurrent somatic mutations, particularly in KCNJ5. Recent single-cell and spatial transcriptomic studies have further revealed cellular and functional heterogeneity within individual APAs. In this issue, Dr. Masanori Murakami at Institute of Science Tokyo reviews recent findings on the inter- and intratumoral heterogeneity of APAs and discusses their clinical implications. This review provides readers with an updated perspective on APA pathophysiology and the evolving understanding of its molecular and cellular heterogeneity.