STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Physiology and clinical applications of GIP

Shunsuke Yamane, Norio Harada, Nobuya Inagaki

https://doi.org/10.1507/endocrj.EJ25-0087
April 3, 2025
CASE REPORT WITH REVIEW OF LITERATURE
p.M918W, a novel RET germline variant: a case report and literature review of the possible association of multiple endocrine neoplasia type 2B and Charcot-Marie-Tooth disease

Mami Sato, Rei Kubota, Shinya Uchino, Takayuki Morita, Ryoyu Niikuni, Teruhisa Udagawa, Yoshiya Hagiwara, Miyako Tanaka, Miku Sato, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kazuhiro Haginoya, Noriaki Nakashima, Keisei Fujimori, Takanori Ishida

https://doi.org/10.1507/endocrj.EJ24-0412
April 1, 2025
REVIEW
Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis

Hironori Bando, Shin Urai, Keitaro Kanie, Masaaki Yamamoto

https://doi.org/10.1507/endocrj.EJ25-0035
March 27, 2025
ORIGINAL
Early postoperative levothyroxine initiation after total thyroidectomy for Graves’ disease

Yuji Nagayama, Seigo Tachibana, Takashi Fukuda, Kento Katsuyama, Daisuke Tatsushima, Yusuke Mori, Hisakazu Shindo, Hiroshi Takahashi, Misa Okamura, Atsushi Yamaoka, Shinya Sato, Hiroyuki Yamashita

https://doi.org/10.1507/endocrj.EJ25-0009
March 27, 2025
ORIGINAL
Disseminated intravascular coagulation as a frequent and critical complication of thyroid storm: a single-center retrospective survey

Ayako Hoshiyama, Akinori Hayashi, Tomomi Taguchi, Yasuhiro Ohata, Akihiko Suzuki, Tsuguto Masaki, Raishi Ichikawa, Yuji Kamata, Takeshi Miyatsuka

https://doi.org/10.1507/endocrj.EJ24-0542
March 22, 2025
ORIGINAL
Severe obesity with hypo-leptinemia

Masanori Kita, Shuhei Morita, Hiroyuki Ariyasu, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Hiroshi Iwakura, Taka-aki Matsuoka

https://doi.org/10.1507/endocrj.EJ24-0568
March 22, 2025
ORIGINAL
The influence of hypertensive disorders of pregnancy on the development of long-term postpartum type 2 diabetes mellitus

Shota Inoue, Yasunori Takata, Yasuharu Tabara, Koutatsu Maruyama, Ayaka Yoshida, Haruhiko Osawa, Takashi Sugiyama

https://doi.org/10.1507/endocrj.EJ25-0033
March 13, 2025
ORIGINAL
Status of temozolomide use without insurance coverage in patients with aggressive pituitary neuroendocrine tumors

Atsushi Ishida, Naoko Inoshita, Noriaki Tanabe, Koji Takano, Hideki Shiramizu, Haruko Yoshimoto, Masataka Kato, Go Matsuoka, Shozo Yamada

https://doi.org/10.1507/endocrj.EJ24-0727
March 11, 2025
ORIGINAL
Establishment of novel prognostic groups for papillary thyroid carcinoma using a modified risk classification based on tumor extension in the guidelines of the Japan Association of Endocrine Surgery

Yasuhiro Ito, Masashi Yamamoto, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya, Akira Miyauchi

https://doi.org/10.1507/endocrj.EJ24-0610
March 8, 2025
CLINICAL PRACTICE GUIDELINE
The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery

Iwao Sugitani, Naomi Kiyota, Yasuhiro Ito, Naoyoshi Onoda, Tomo Hiromasa, Kiyomi Horiuchi, Seigo Kinuya, Tetsuo Kondo, Sueyoshi Moritani, Kiminori Sugino, Hisato Hara

https://doi.org/10.1507/endocrj.EJ24-0644
March 8, 2025
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Management of Cushing’s disease in the initial phase~From detection to surgery~

Hidenori Fukuoka

https://doi.org/10.1507/endocrj.EJ24-0309
March 7, 2025
ORIGINAL
Utility of the random C-peptide and random C-peptide index at diagnosis as a predictor of disease type and long-term insulin secretory capacity in children with diabetes mellitus

Keita Numasawa, Kentaro Shiga, Makiko Kitao, Hiroaki Konno, Kuniyuki Nishiyama, Koji Ohsugi, Kanako Ebina, Nobuyuki Kikuchi, Shuichi Ito

https://doi.org/10.1507/endocrj.EJ24-0517
March 5, 2025
ORIGINAL
The prognosis of severe subclinical hyperthyroidism with TSH below 0.1 μU/mL due to Graves’ disease in the Japanese population

Yui Nishijima, Tsukasa Murakami, Naoyuki Higaki, Junichi Tani, Hitoshi Noguchi

https://doi.org/10.1507/endocrj.EJ24-0424
February 26, 2025
ORIGINAL
Scutellarin mitigates high glucose-induced pyroptosis in diabetic atherosclerosis: Role of Nrf2-FBXL2-mediated NLRP3 degradation

Qingxin Meng, Yongpan Huang, Xian Long, Lijing Liu, Yani Tang, Jingjing He, Yayuan Luo

https://doi.org/10.1507/endocrj.EJ24-0505
February 26, 2025
ORIGINAL
Association of uric acid levels with the development of metabolic dysfunction-associated and metabolic and alcohol-related/associated steatotic liver disease: a study on Japanese participants undergoing health checkups

Tatsuya Fukuda, Taro Akihisa, Takahiro Okamoto, Takahiro Fukaishi, Akio Kawakami, Makoto Tanaka, Tetsuya Yamada, Koshiro Monzen

https://doi.org/10.1507/endocrj.EJ24-0622
February 26, 2025
ORIGINAL
Influence of therapeutic inorganic iodine on long-term prognosis of Graves’ disease: a multicenter prospective observational study

Hiroki Takizawa, Toyoyoshi Uchida, Nami Suzuki, Hiroyuki Onose, Emiko Yamada, Koshi Hashimoto, Natsuko Watanabe, Yuya Nishida, Hirotaka Watada

https://doi.org/10.1507/endocrj.EJ24-0575
February 22, 2025
ORIGINAL
Persistence to growth hormone treatment and clinical characteristics of pediatric patients with growth hormone deficiency: A retrospective cohort study of data from the Japan Medical Data Center claims database

Sumito Dateki, Yukihito Sato, Satoshi Tsuboi, Jun Mori

https://doi.org/10.1507/endocrj.EJ24-0225
February 20, 2025
ORIGINAL
Assessing the potential of high-mobility group AT-hook 2 immunohistochemical staining as a prognostic marker of metastatic recurrence in follicular thyroid cancer: a retrospective cohort study

Yuka Ito, Junko Sakumoto, Hideki Hirabayashi, Shinichi Haruna, Wataru Konno, Itsuo Nakajima, Kazuyuki Ishida, Yasuo Haruyama, Toshimi Sairenchi, Eijun Nishihara, Shuji Fukata, Akira Hishinuma, Takahiko Kogai

https://doi.org/10.1507/endocrj.EJ24-0557
February 19, 2025
CASE REPORT WITH REVIEW OF LITERATURE
Pheochromocytoma associated with ectopic ACTH-producing tumor and hyper-interleukin-6emia: a case report with review of literature

Hironori Nakahira, Shozo Miyauchi, Kyoko Watanabe, Kazuyuki Akesaka, Keizo Ono, Osamu Ebisui, Teruki Miyake, Shinya Furukawa, Yoichi Hiasa, Bunzo Matsuura

https://doi.org/10.1507/endocrj.EJ24-0459
February 14, 2025
ORIGINAL
Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study

Hajime Nawata, Li Ou, Xu Zhang, Qinglan Song, Jing Huang, Jin Hu, Kazue Ito, Shinichi Obo, Takeharu Fukushima, Kaori Iwami, Shizuka Iguchi, Ai Igarashi, Xiaoyang He, Jing Zhang, Yu Xia, Ken Takasaki

https://doi.org/10.1507/endocrj.EJ24-0554
February 14, 2025
ORIGINAL
Association between gestational weight gain and pregnancy outcomes, neonatal birth weight, and maternal postpartum glucose tolerance in Japanese gestational diabetes mellitus patients: comparison of old and new gestational weight gain standards

Akiho Yamashita, Masayuki Kaku, Takuya Ideguchi, Shuhei Nishida, Hiroyuki Kinoshita, Takeshi Nishikawa

https://doi.org/10.1507/endocrj.EJ24-0486
February 5, 2025
NOTE
Association between serum thyroglobulin levels and glycemic control in patients with thyroid cancer after radioiodine therapy

Yuji Hataya, Yuko Fujishima, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka

https://doi.org/10.1507/endocrj.EJ24-0417
February 1, 2025
ORIGINAL
Long-term outcomes after a radioactive iodine treatment for a single autonomous functioning thyroid nodule in Japan

Ai Yoshihara, Jaeduk Yoshimura Noh, Kosuke Inoue, Masakazu Koshibu, Rei Hirose, Masahiro Ichikawa, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Natsuko Watanabe, Kiminori Sugino, Koichi Ito

https://doi.org/10.1507/endocrj.EJ24-0578
January 23, 2025
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Ghrelin–LEAP2 interactions along the stomach–liver axis

Katsuya Sakai, Yuki Nakazato, Yuki Shiimura, Weidong Zhang, Masamitsu Nakazato

https://doi.org/10.1507/endocrj.EJ24-0543
 Featured Article  Vol 72 Issue 4 (April, 2025)
ORIGINAL
Hypertriglyceridemia and younger age are associated with effectiveness of growth hormone therapy on hepatic steatosis

Tomomi Taguchi, Shiori Ito, Rei Fujishima, Naoya Shimizu, Wataru Hagiwara, Kenta Matoba, Masatoshi Hirose, Akinori Hayashi, Koji Takano, Takeshi Miyatsuka

https://doi.org/10.1507/endocrj.EJ24-0481
Vol 72 Issue 4 (April, 2025)
ORIGINAL
Characteristics of patients with Graves’ disease who developed drug resistance and required surgery

Yusuke Shibata, Ako Oiwa, Hiroki Tanaka, Satoshi Kubota, Ken-ichi Ito, Mitsuhisa Komatsu

https://doi.org/10.1507/endocrj.EJ24-0494
Vol 72 Issue 4 (April, 2025)
ORIGINAL
Handgrip strength in patients with type 2 diabetes correlates with diabetic polyneuropathy. A single-center, retrospective observational study in Japanese patients

Yuichiro Iwamoto, Shuhei Nakanishi, Masahiro Komi, Yuto Kimura, Yuki Watanabe, Taku Sasaki, Erina Nakao, Masato Kubo, Toshitomo Sugisaki, Kazunori Dan, Yui Okamoto, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Tomohiko Kimura, Masashi Shimoda, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

https://doi.org/10.1507/endocrj.EJ24-0397
Vol 72 Issue 4 (April, 2025)
ORIGINAL
Prediction of insulin resistance using multiple adaptive regression spline in Chinese women

Shih-Peng Mao, Chen-Yu Wang, Chi-Hao Liu, Chung-Bao Hsieh, Dee Pei, Ta-Wei Chu, Yao-Jen Liang

https://doi.org/10.1507/endocrj.EJ24-0449
Vol 72 Issue 4 (April, 2025)
ORIGINAL
Clinicopathological and genomic analysis of pediatric pheochromocytoma and sympathetic paraganglioma

Noriko Kimura, Koji Muroya, Masato Yonamine, Kazuhiro Takekoshi, Takeshi Sato, Rei Hirose, Takato Sasaki, Kana Tamai, Hiroyo Mabe, Junji Kawashima, Hiromichi Kijima, Yuki Naruke, Takuyuki Katabami

https://doi.org/10.1507/endocrj.EJ24-0584
Vol 72 Issue 4 (April, 2025)
CASE REPORT WITH REVIEW OF LITERATURE
Intragenic duplication of PHEX in a girl with X-linked hypophosphatemia: a case report with review of literature

Kazuhisa Akiba, Keiko Matsubara, Atsushi Hattori, Maki Fukami

https://doi.org/10.1507/endocrj.EJ24-0355
Vol 72 Issue 4 (April, 2025)
CASE REPORT WITH REVIEW OF LITERATURE
Short- and long-term glycemic effects of pasireotide in patients with acromegaly: a comprehensive case study with review of literature

Yuki Taki, Takashi Kono, Tatsuma Matsuda, Ryunosuke Kozu, Masanori Fujimoto, Ikki Sakuma, Naoko Hashimoto, Kentaro Horiguchi, Yoshinori Higuchi, Tomoaki Tanaka

https://doi.org/10.1507/endocrj.EJ24-0548
Vol 72 Issue 4 (April, 2025)
CASE REPORT WITH REVIEW OF LITERATURE
Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature

Seiji Nishikage, Masaaki Yamamoto, Takahiro Niikura, Yuiko Inaba, Tomoyuki Akiyama, Risa Harada, Yoshitada Sakai, Kenji Sugawara, Kanako Tachikawa, Toshimi Michigami, Wataru Ogawa, Hidenori Fukuoka

https://doi.org/10.1507/endocrj.EJ24-0431
Vol 72 Issue 4 (April, 2025)

Volume 72 (2025) Issue 4

EJ24-0543

Recommendation from the Editor in Chief

There are examples where distinct two peptide ligands respectively act as an agonist and antagonist on the same receptor. To my knowledge, the best-known one is related with the story that alpha-MSH and agouti-related peptide (AgRP) act on the melanocrtin-4 receptor (MC4R) as an agonist and antagonist, thereby minutely regulating appetite and body weight. In this issue, Dr. Katsuya Sakai and Professor Masamitsu Nakazato, a world-renowned physician scientist on research of orexigenic hormone ghrelin, provide us with well-organized, fabulous review article focusing on the dynamic interaction between ghrelin and LEAP-2 (liver-expressed antimicrobial peptide 2) in terms of stomach-liver axis-driven appetite control. Indeed, ghrelin and LEAP-2 respectively act as an agonist and antagonist on the same receptor, GHSR (growth hormone secretagogue receptor). Our editorial team has a firm belief that all readers are surely motivated by the real deal of authentic endocrinology and cutting-edge medicine on GPCR signal transduction in this article.

Ghrelin–LEAP2 interactions along the stomach–liver axis

Katsuya Sakai, Yuki Nakazato, Yuki Shiimura, Weidong Zhang, Masamitsu Nakazato

https://doi.org/10.1507/endocrj.EJ24-0543

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