ORIGINAL
Shinta Yamamoto, Hiroshi Okada, Natsuko Shinagawa, Nozomi Kuramoto, Yuriko Ono, Megumi Minamida, Junya Hironaka, Chihiro Munekawa, Yuka Hasegawa, Hanako Nakajima, Nobuko Kitagawa, Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Noriyuki Kitagawa, Rieko Nakatani, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui
Vol 72 Issue 8 (August, 2025)
Recommendation from the Editor in Chief
Hypoparathyroidism is commonly caused by neck surgery for thyroid malignancy and rarely by genetic problems. Noteworthy is the observation that even when the level of circulating calcium (Ca) is within normal range, quality of life (QOL) in patents with hypothyroidism receiving conventional therapy such as oral intake of Ca and vitamin D analogs is apparently inferior, underscoring the negative impact of parathyroid hormone (PTH) deficiency per se on such a decline of QOL. In this issue, Dr. Mayuko Kano at St. Marianna University contributes an elegant, updated review article particularly focusing on how to generate parathyroid glands from pluripotent stem cells via blastocyst complementation (BC). A line of cutting-edge approach does open a fresh avenue of regenerative medicine for basic research and clinics in endocrinology.