STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Management of Cushing’s disease in the initial phase~From detection to surgery~

Hidenori Fukuoka

https://doi.org/10.1507/endocrj.EJ24-0309
 Featured Article  Vol 72 Issue 5 (May, 2025)
ESSAY | TOWARD JES 100TH ANNIVERSARY
A 40-year challenge to resolve clinical questions through experimental/laboratory techniques

Yasumasa Iwasaki

https://doi.org/10.1507/endocrj.EJ20250116
Vol 72 Issue 5 (May, 2025)
ESSAY | TOWARD JES 100TH ANNIVERSARY
I am deeply indebted to the Japan Endocrine Society

Yutaka Oki

https://doi.org/10.1507/endocrj.EJ20250203
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Persistence to growth hormone treatment and clinical characteristics of pediatric patients with growth hormone deficiency: A retrospective cohort study of data from the Japan Medical Data Center claims database

Sumito Dateki, Yukihito Sato, Satoshi Tsuboi, Jun Mori

https://doi.org/10.1507/endocrj.EJ24-0225
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Long-term outcomes after a radioactive iodine treatment for a single autonomous functioning thyroid nodule in Japan

Ai Yoshihara, Jaeduk Yoshimura Noh, Kosuke Inoue, Masakazu Koshibu, Rei Hirose, Masahiro Ichikawa, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Natsuko Watanabe, Kiminori Sugino, Koichi Ito

https://doi.org/10.1507/endocrj.EJ24-0578
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Scutellarin mitigates high glucose-induced pyroptosis in diabetic atherosclerosis: Role of Nrf2-FBXL2-mediated NLRP3 degradation

Qingxin Meng, Yongpan Huang, Xian Long, Lijing Liu, Yani Tang, Jingjing He, Yayuan Luo

https://doi.org/10.1507/endocrj.EJ24-0505
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Association between gestational weight gain and pregnancy outcomes, neonatal birth weight, and maternal postpartum glucose tolerance in Japanese gestational diabetes mellitus patients: comparison of old and new gestational weight gain standards

Akiho Yamashita, Masayuki Kaku, Takuya Ideguchi, Shuhei Nishida, Hiroyuki Kinoshita, Takeshi Nishikawa

https://doi.org/10.1507/endocrj.EJ24-0486
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study

Hajime Nawata, Li Ou, Xu Zhang, Qinglan Song, Jing Huang, Jin Hu, Kazue Ito, Shinichi Obo, Takeharu Fukushima, Kaori Iwami, Shizuka Iguchi, Ai Igarashi, Xiaoyang He, Jing Zhang, Yu Xia, Ken Takasaki

https://doi.org/10.1507/endocrj.EJ24-0554
Vol 72 Issue 5 (May, 2025)
ORIGINAL
Assessing the potential of high-mobility group AT-hook 2 immunohistochemical staining as a prognostic marker of metastatic recurrence in follicular thyroid cancer: a retrospective cohort study

Yuka Ito, Junko Sakumoto, Hideki Hirabayashi, Shinichi Haruna, Wataru Konno, Itsuo Nakajima, Kazuyuki Ishida, Yasuo Haruyama, Toshimi Sairenchi, Eijun Nishihara, Shuji Fukata, Akira Hishinuma, Takahiko Kogai

https://doi.org/10.1507/endocrj.EJ24-0557
Vol 72 Issue 5 (May, 2025)
CLINICAL PRACTICE GUIDELINE
The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery

Iwao Sugitani, Naomi Kiyota, Yasuhiro Ito, Naoyoshi Onoda, Tomo Hiromasa, Kiyomi Horiuchi, Seigo Kinuya, Tetsuo Kondo, Sueyoshi Moritani, Kiminori Sugino, Hisato Hara

https://doi.org/10.1507/endocrj.EJ24-0644
Vol 72 Issue 5 (May, 2025)
NOTE
Association between serum thyroglobulin levels and glycemic control in patients with thyroid cancer after radioiodine therapy

Yuji Hataya, Yuko Fujishima, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka

https://doi.org/10.1507/endocrj.EJ24-0417
Vol 72 Issue 5 (May, 2025)

» Archives

Volume 72 (2025) Issue 5

EJ24-0309

Recommendation from the Editor in Chief

As well known, Cushing’s disease is a symbolic endocrine disorder in which a variety of basic, clinical, diagnostic and therapeutic insights are crystallized. Unexpectedly, however, there have still been unsolved issues in early diagnosis, interpretation for endocrinologic testing, and preoperative management. To better understand the latest situation around the clinics on Cushing’s disease, Dr. Hidenori Fukuoka seasonably provides a fascinating and comprehensive overview in the May Issue. Our editorial team has a firm belief that all readers will definitely be satisfied by the empirical knowledge of an expert endocrinologist.

Management of Cushing’s disease in the initial phase~From detection to surgery~

Hidenori Fukuoka

https://doi.org/10.1507/endocrj.EJ24-0309

» Archives

ORIGINAL
Impact of pre-pregnant body mass index and gestational weight gain on the development of hypertensive disorders of pregnancy: the KODMO study

Yuka Matoba, Misato Ishikawa, Natsuo Tsutsumida, Kentaro Yamada, Naohiro Imazono, Kano Hayashi, Junki Abe, Kosuke Kawakami, Naofumi Ookura, Yoshihiro Ogawa

https://doi.org/10.1507/endocrj.EJ25-0031
May 9, 2025
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Biased antibodies and beyond: a new era in the diagnosis of PTH-dependent hypercalcemia

Noriko Makita, Katsunori Manaka, Maho Taguchi, Hirofumi Horikoshi, Junichiro Sato, Taroh Iiri

https://doi.org/10.1507/endocrj.EJ25-0051
May 3, 2025
ORIGINAL
Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial

Jaeduk Yoshimura Noh, Natsuko Watanabe, Koichi Ito, Mika Tsuiki, Yuki Ishihara, Tetsuya Tagami, Ichiro Yamauchi, Ai Kozaki, Toshu Inoue, Bernard Rees Smith

https://doi.org/10.1507/endocrj.EJ25-0043
April 29, 2025
ORIGINAL
Clinicopathological features of follicular thyroid carcinoma coexisting with papillary thyroid carcinoma

Wang Hong-qun, Ma Ya-qi, Li Ying, Shi Huai-yin

https://doi.org/10.1507/endocrj.EJ24-0523
April 24, 2025
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Clinical approaches to osteoporosis in patients with chronic kidney disease: A comprehensive review

Yasuo Imanishi, Taku Furukubo, Shigeichi Shoji

https://doi.org/10.1507/endocrj.EJ24-0271
April 23, 2025
REVIEW
Generation of parathyroid glands from pluripotent stem cells

Mayuko Kano

https://doi.org/10.1507/endocrj.EJ25-0069
April 22, 2025
ORIGINAL
The predictive value of miR-28-5p and miR-424-5p in metabolic syndrome and their mechanism of action through regulation of Fras-1-related extracellular matrix protein 2

Guangfeng Tang, Tongtong Shen

https://doi.org/10.1507/endocrj.EJ24-0539
April 19, 2025
ORIGINAL
Association between total bilirubin and sarcopenia in people with type 2 diabetes: The KAMOGAWA-A study

Shinta Yamamoto, Hiroshi Okada, Natsuko Shinagawa, Nozomi Kuramoto, Yuriko Ono, Megumi Minamida, Junya Hironaka, Chihiro Munekawa, Yuka Hasegawa, Hanako Nakajima, Nobuko Kitagawa, Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Noriyuki Kitagawa, Rieko Nakatani, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui

https://doi.org/10.1507/endocrj.EJ24-0612
April 17, 2025
REVIEW
Risk factors and prediction for pediatric obesity: current status and future perspectives

Shiori Minabe, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Shohei Komaki, Motoki Nakao, Hideki Ohmomo, Yutaka Hasegawa, Yasushi Ishigaki, Kozo Tanno, Makoto Sasaki, Atsushi Shimizu

https://doi.org/10.1507/endocrj.EJ24-0724
April 9, 2025
ORIGINAL
Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota

Jing Han, Congfu Huang, Lingjuan Meng, Hui Wu, Dongming Meng

https://doi.org/10.1507/endocrj.EJ24-0615
April 5, 2025
STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY
Physiology and clinical applications of GIP

Shunsuke Yamane, Norio Harada, Nobuya Inagaki

https://doi.org/10.1507/endocrj.EJ25-0087
April 3, 2025
CASE REPORT WITH REVIEW OF LITERATURE
p.M918W, a novel RET germline variant: a case report and literature review of the possible association of multiple endocrine neoplasia type 2B and Charcot-Marie-Tooth disease

Mami Sato, Rei Kubota, Shinya Uchino, Takayuki Morita, Ryoyu Niikuni, Teruhisa Udagawa, Yoshiya Hagiwara, Miyako Tanaka, Miku Sato, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kazuhiro Haginoya, Noriaki Nakashima, Keisei Fujimori, Takanori Ishida

https://doi.org/10.1507/endocrj.EJ24-0412
April 1, 2025
REVIEW
Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis

Hironori Bando, Shin Urai, Keitaro Kanie, Masaaki Yamamoto

https://doi.org/10.1507/endocrj.EJ25-0035
March 27, 2025
ORIGINAL
Early postoperative levothyroxine initiation after total thyroidectomy for Graves’ disease

Yuji Nagayama, Seigo Tachibana, Takashi Fukuda, Kento Katsuyama, Daisuke Tatsushima, Yusuke Mori, Hisakazu Shindo, Hiroshi Takahashi, Misa Okamura, Atsushi Yamaoka, Shinya Sato, Hiroyuki Yamashita

https://doi.org/10.1507/endocrj.EJ25-0009
March 27, 2025
ORIGINAL
Disseminated intravascular coagulation as a frequent and critical complication of thyroid storm: a single-center retrospective survey

Ayako Hoshiyama, Akinori Hayashi, Tomomi Taguchi, Yasuhiro Ohata, Akihiko Suzuki, Tsuguto Masaki, Raishi Ichikawa, Yuji Kamata, Takeshi Miyatsuka

https://doi.org/10.1507/endocrj.EJ24-0542
March 22, 2025
ORIGINAL
Severe obesity with hypo-leptinemia

Masanori Kita, Shuhei Morita, Hiroyuki Ariyasu, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Hiroshi Iwakura, Taka-aki Matsuoka

https://doi.org/10.1507/endocrj.EJ24-0568
March 22, 2025
ORIGINAL
The influence of hypertensive disorders of pregnancy on the development of long-term postpartum type 2 diabetes mellitus

Shota Inoue, Yasunori Takata, Yasuharu Tabara, Koutatsu Maruyama, Ayaka Yoshida, Haruhiko Osawa, Takashi Sugiyama

https://doi.org/10.1507/endocrj.EJ25-0033
March 13, 2025
ORIGINAL
Status of temozolomide use without insurance coverage in patients with aggressive pituitary neuroendocrine tumors

Atsushi Ishida, Naoko Inoshita, Noriaki Tanabe, Koji Takano, Hideki Shiramizu, Haruko Yoshimoto, Masataka Kato, Go Matsuoka, Shozo Yamada

https://doi.org/10.1507/endocrj.EJ24-0727
March 11, 2025
ORIGINAL
Establishment of novel prognostic groups for papillary thyroid carcinoma using a modified risk classification based on tumor extension in the guidelines of the Japan Association of Endocrine Surgery

Yasuhiro Ito, Masashi Yamamoto, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya, Akira Miyauchi

https://doi.org/10.1507/endocrj.EJ24-0610
March 8, 2025
ORIGINAL
Utility of the random C-peptide and random C-peptide index at diagnosis as a predictor of disease type and long-term insulin secretory capacity in children with diabetes mellitus

Keita Numasawa, Kentaro Shiga, Makiko Kitao, Hiroaki Konno, Kuniyuki Nishiyama, Koji Ohsugi, Kanako Ebina, Nobuyuki Kikuchi, Shuichi Ito

https://doi.org/10.1507/endocrj.EJ24-0517
March 5, 2025
ORIGINAL
The prognosis of severe subclinical hyperthyroidism with TSH below 0.1 μU/mL due to Graves’ disease in the Japanese population

Yui Nishijima, Tsukasa Murakami, Naoyuki Higaki, Junichi Tani, Hitoshi Noguchi

https://doi.org/10.1507/endocrj.EJ24-0424
February 26, 2025
ORIGINAL
Association of uric acid levels with the development of metabolic dysfunction-associated and metabolic and alcohol-related/associated steatotic liver disease: a study on Japanese participants undergoing health checkups

Tatsuya Fukuda, Taro Akihisa, Takahiro Okamoto, Takahiro Fukaishi, Akio Kawakami, Makoto Tanaka, Tetsuya Yamada, Koshiro Monzen

https://doi.org/10.1507/endocrj.EJ24-0622
February 26, 2025
ORIGINAL
Influence of therapeutic inorganic iodine on long-term prognosis of Graves’ disease: a multicenter prospective observational study

Hiroki Takizawa, Toyoyoshi Uchida, Nami Suzuki, Hiroyuki Onose, Emiko Yamada, Koshi Hashimoto, Natsuko Watanabe, Yuya Nishida, Hirotaka Watada

https://doi.org/10.1507/endocrj.EJ24-0575
February 22, 2025
CASE REPORT WITH REVIEW OF LITERATURE
Pheochromocytoma associated with ectopic ACTH-producing tumor and hyper-interleukin-6emia: a case report with review of literature

Hironori Nakahira, Shozo Miyauchi, Kyoko Watanabe, Kazuyuki Akesaka, Keizo Ono, Osamu Ebisui, Teruki Miyake, Shinya Furukawa, Yoichi Hiasa, Bunzo Matsuura

https://doi.org/10.1507/endocrj.EJ24-0459
February 14, 2025