CLINICAL PRACTICE GUIDELINE
Tomohiro Ishii, Kenichi Kashimada, Masanobu Kawai, Tomoyo Itonaga, Takeshi Iwasa, Akari Utsunomiya, Kayo Ozaki, Kazuhiro Kawamura, Junko Kanno, Jun Koh, Yoshiyuki Kojima, Shoko Sasaki, Hiroyuki Sato, Koji Shiraishi, Yasuhiro Naiki, Mitsuru Nishiyama, Takashi Hamajima, Yasuko Fujisawa, Noriko Makita, Katsuyuki Matsui, Toshihiro Yanai, Reiko Horikawa, Tsutomu Ogata
December 3, 2025
Recommendation from the Editor in Chief
Inter-relationship between body weight regulation and fertility has long fascinated researchers and clinicians in the area of endocrinology. However, an avalanche of enigmas still remains around the molecular mechanism. In this issue, Dr. Yuki Otsuka, Dr. Yoshitaka Uenoyama, Professor Hiroko Tsukamura and colleague at Nagoya University unravel a role of “orphan ligand” receptor, GPR75, in the control of appetite and reproduction in knockout rat models. Because loss of function variants of GPR75 gene is implicated in the protection of obesity in humans via the worldwide, large-scale exome sequencing, this excellent article provides all readers with fresh avenue to integrate the latest genome science and such a sophisticated basic research.